Erythropoietin induction in Hep3B cells is not affected by inhibition of heme biosynthesis
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چکیده
منابع مشابه
Induction of Phenolic Compounds is Affected by Boron Supply in Marshmallow (Althaea officinalis L. ) Cells
Boron (B) is a non-metal micronutrient which is essential for plants growth and development. Formation of boron complex with cell wall matrix and phenolic compounds is a definite influence of boron in physiological process. It has been suggested that B-toxicity and deficiency may induce excess production of reactive oxygen species thereby promote defense responses by antioxidant enzymes or non-...
متن کاملErythropoietin signaling regulates heme biosynthesis
Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown. Here, using zebrafish, murine, and human models, we show that erythropoietin (EPO) signaling, together with the GATA1 transcriptional target, AKAP...
متن کاملErythropoietin-induced stimulation of differentiation and proliferation in J2E cells is not mimicked by chemical induction.
The J2E cell line is a novel erythroid cell line that differentiates in response to erythropoietin (Epo), the physiologic stimulus for erythropoiesis. After exposure to Epo, the cells synthesize hemoglobin, and we show here that this process is tightly linked to increases in cellular proliferation and DNA synthesis. The hormone-induced terminal differentiation also results in morphologic altera...
متن کاملinduction of phenolic compounds is affected by boron supply in marshmallow (althaea officinalis l. ) cells
boron (b) is a non-metal micronutrient which is essential for plants growth and development. formation of boron complex with cell wall matrix and phenolic compounds is a definite influence of boron in physiological process. it has been suggested that b-toxicity and deficiency may induce excess production of reactive oxygen species thereby promote defense responses by antioxidant enzymes or non-...
متن کاملRunning head : Induction of Heme Biosynthesis by Oxidative Stresses
2 Induction of isoforms of tetrapyrrole biosynthetic enzymes, atHEMA2 and atFC1, under stress conditions and their physiological functions in Arabidopsis thaliana Abstract In the tetrapyrrole biosynthetic pathway, isoforms of glutamyl-tRNA reductase (HEMA2) and ferrochelatase (FC1) are mainly expressed in non-photosynthetic tissues. Here, using promoter-GUS constructs, we showed that the expres...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2000
ISSN: 0167-4889
DOI: 10.1016/s0167-4889(99)00169-x